Deltamikrons: Delta-Omikronu rekombinants ar hibrīdiem genomiem  

Iepriekš tika ziņots par vienlaicīgu infekciju gadījumiem ar diviem variantiem. Nav daudz zināms par vīrusu rekombināciju, kas rada vīrusus ar hibrīdiem genomiem. Divos nesenos pētījumos ziņots par ģenētiskās rekombinācijas gadījumiem starp SARS-CoV-2 variantiem Denta un Omicron. Rekombinantam, ko sauc par Deltamikronu, bija abu variantu iezīmes.  

Termins "Deltacron" parādījās šī gada sākumā¹ to denote COVID-19 cases of co-infection of people with the different variants of SARS-Cov-2 variants, e.g. delta and omicron. Delmicron or Deltacron referred to the infection caused by a combination of “two variants of the same strain of virus, SARS CoV-2″, and were not said to be different “celmi".  

However, cases of genetic recombination between two different strains of SARS-CoV-2 have been reported recently. On 08 March 2022, researchers² reported three infections in southern France with “Deltamicron” recombinant with hybrid Genoma that had spike protein from an Omicron variant and the “body” of a Delta variant. The hybrid Genoma had signature mutations of the two lineages. The recombinant spike could optimise viral binding to the host cell membrane.  

Evidences for Delta and Omicron recombination has emerged from USA³ as well. This team could identify two independent cases of Delta-Omicron recombinant. In both cases, the 5′-end of the viral Genoma was from the Delta Genoma, and the 3′-end from Omicron.  

It is suggested that the recombinant viruses are not common nor there is any evidence to suggest that the recombinants with hybrid genomi are more transmissible or virulent than the dominant circulating variants.  

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Norādes:  

1. Deltacron nav jauns celms vai variants. Zinātniskais eiropietis. Publicēts 9. gada 2022. janvārī. Pieejams plkst http://scientificeuropean.co.uk/covid-19/deltacron-is-not-a-new-strain-or-variant/  

2. Kolsons, P., un citi 2022. gads. “Deltamicron” SARS-CoV-2 kultūra un identificēšana trīs gadījumu grupā Francijas dienvidos. Iepriekšēja izdruka medRxiv. Publicēts 08. gada 2022. martā. DOI: https://doi.org/10.1101/2022.03.03.22271812  

3. Bolže A., un citi 2022. gads. Pierādījumi par SARS-CoV-2 Delta un Omicron koinfekcijām un rekombināciju. Iepriekšēja izdruka medRxiv. Publicēts 12. gada 2022. martā. DOI: https://doi.org/10.1101/2022.03.09.22272113 

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